College of Medicine, Inha University
CANCER THERAPEUTICS LABORATORY
International Journal
PUBLICATION
2024
Jung KH, Lee S, Kim HS, Kim JK, Lee YJ, Park MS, Seo MS, Lee M, Yun M, Park S, Hong SS* (2024.03) Acetyl-CoA synthetase 2 contributes to better prognosis for liver cancer through switch of acetate-glucose metabolism. Experimental and Molecular Medicine.
2023
Jung KH, Kim SE, Go HG, Lee YJ, Park MS, Ko S, Han BS, Yoon YC, Cho YJ, Lee P, Lee SH, Kim K, Hong SS* (2023.05.15) Synergistic renoprotective effect of melatonin and zileuton by inhibition of ferroptosis via the AKT/mTOR/NRF2 signaling in kidney injury and fibrosis. Biomolecules & Therapeutics. Online ahead of print
Lee JE, Lee P, Yoon YC, Han BS, Ko S, Park MS, Lee YJ, Kim SE, Cho YJ, Lim JH, Ryu JK, Shim S, Kim DK, Jung KH, Hong SS* (2023.06) Vactosertib, TGF-β receptor I inhibitor, augments the sensitization of the anti-cancer activity of gemcitabine in pancreatic cancer. Biomedicine & Pharmacotherapy. 162: 114716
Hyun GH, Jeong DH, Yang YY, Cho IH, Ha YJ, Xing X, Abbott DW, Hsieh YSY, Kang YP, Cha JH, Hong SS, Lee SJ, Kim YS, Kwon SW. (2023.06.27) Multivalent carbohydrate nanocomposites for tumor microenvironment remodeling to enhance antitumor immunity. ACS Nano. 17(12):11567-11582
Ock J, Wu J, Liu FY, Fridayana FR, Niloofar L, Vo MN, Hong SS, Kang JH, Suh JK, Yin GN, Jin HR, Ryu JK (2023.05.11) Heme-binding protein 1 delivered via pericyte-derived extracellular vesicles improves neurovascular regeneration in a mouse model of cavernous nerve injury. International Journal of Biological Sciences. 19(9):2663-2677
Jeon B, Lee YJ, Shin J, Choi MJ, Lee CE, Son MK, Park JH, Kim BS, Kim HR, Jung KH, Cha JH, Hong SS*(2023.02.15) A combination of BR101801 and venetoclax enhances antitumor effect in DLBCL cells via c-Myc/Bcl-2/Mcl-1 triple targeting American Journal of Cancer Research. 13(2): 452-463
Liu FY, Yin G, Ock J, Fridayana FR, Niloofar L, Huang Y, Vo MN, Suh JK, Hong SS,
Kang JH, Ryu JK (2023.02.02) Argonaute 2 restores erectile function by enhancing angiogenesis and reducing reactive oxygen species production in diabetic mice. International Journal of Molecular Medicine. 24(3): 2935
Oh S, Jo S, Kim HS, Mai VH, Endaya B, Neuzil J, Jung KH, Hong SS, Kim JM, Park S (2023.01.17) Chemical biopsy for GNMT as noninvasive and tumorigenesis-relevant diagnosis of liver cancer. Analytical Chemistry. 95(2):1184-1192 (IF= 8.008)e. Andrology. 11(2): 358-371
2022
Ghatak K, Yin GN, Hong SS, Kang JH, Suh JK, Ryu JK (2022.10). Heat Shock Protein 70 in Penile Neurovascular Regeneration Requires Cystathionine Gamma-Lyase. World Journal of Men’s Health. 40(4):580-599
Ko S, Jung KH, Yoon YC, Han BS, Park MS, Lee YJ, Kim SE, Cho YJ, Lee P, Lim JH, Ryu JK, Kim K, Kim TY, Hong S, Lee SH, Hong SS*(2022.09.15) A novel DDR1 inhibitor enhances the anticancer activity of gemcitabine in pancreatic cancer. American Journal of Cancer Research. 12(9): 4326-4342
Seo MS, Jung KH, Kim K, Lee JE, Han BS, Ko S, Kim JH, Hong S, Lee S, Hong SS* (2022.08.01) Discovery of a novel NUAK1 inhibitor against pancreatic cancer. Biomedicine & Pharmacotherapy. 152: 113241
Han BS, Jung KH, Lee JE, Yoon YC, Ko S, Park MS, Lee YJ, Kim SE, Cho YJ, Lee P, Lim JH, Jang E, Kim H, Hong SS * (2022.07.15) Lidocaine enhances the efficacy of palbociclib in triple-negative breast cancer. American Journal of Cancer Research. 12(7): 3083-3098
Anita L, Yin GN, Hong SS, Kang JH, Gho YS, Suh JK, Ryu JK (2022.05.16) Pericyte-derived extracellular vesicle-mimetic nanovesicles ameliorate erectile dysfunction via lipocalin 2 in diabetic mice. International Journal of Biological Sciences 18(9):3653-3667
Lee JY, Kang MH, Jang JE, Lee JE, Yang Y, Choi JY, Kang HS, Lee U, Choung JW, Jung H, Yoon YC, Jung KH, Hong SS, Yi EC, Park SG (2022.05.21) Comparative analysis of mesenchymal stem cells cultivated in serum free media. Scientific Reports 12(1):8620
Lee H, Park JH, Jung KH, Lim JH, Hong SS* (2022.04) HS -173, a novel PI3K inhibitor enhances radiosensitivity of breast cancer cells. International Journal of Radiation Research. 20(2) 347-352
Lee JE, Woo MK, Jung KH, Kang YW, Shin SM, Son MK, Fang Z, Yan HH, Park JH, Yoon YC, Kim YS, Hong SS* (2022.05.01) Combination therapy of the active KRAS-targeting antibody inRas37 and a PI3K inhibitor in pancreatic cancer. Biomolecules & Therapeutics. 20(3): 274-283
Nam HS, Hong SS*, Jung KH, Kang S, Park MS, Kang S, Kim HS, Mai VH, Kim J, Lee Ho, Lee W, Suh YJ, Lim JH, Kim SY, Kim SC, Kim SH, Park S (2022.02.07) A serum marker for early pancreatic cancer with a possible link to diabetes. Journal of the National Cancer Institute. 114(2): 228-234 (co-first)
Yin GN, Shin TY, Ock J, Choi MJ, Limanjaya A, Kwon MH, Liu FY, Hong SS, Kang JH, Gho YS, Suh JK, Ryu JK (2022.02) Pericyte‑derived extracellular vesicles‑mimetic nanovesicles improves peripheral nerve regeneration in mouse models of sciatic nerve transection. International Journal of Molecular Medicine. 49(2):18
2021
Yan HH, Jung KH, Lee JE, Son MK, Fang JH, Park JH, Kim SJ, Kim J, Lim JH, Hong SS* (2021.10.28) ANGPTL4 accelerates KRASG12D-Induced acinar to ductal metaplasia and pancreatic carcinogenesis. Cancer Letters 519: 185-198 (IF=8.679)
Cha JH, Jeong Y, Oh AR, Lee SB, Hong SS, Kim K (2021.09.30) Emerging roles of PHLPP phosphatases in metabolism. BMP Reports. 54(9): 451-457
Lee JE, Kang YW, Jung KH, Son MK, Shin SM, Kim JS, Kim SJ, Fang Z, Yan HH, Park JH, Yoon YC, Han B, Cheon MJ, Woo MG, Seo MS, Lim JH, Kim YS, Hong SS* (2021.06) Intracellular KRAS-specific antibody enhances the anti-tumor efficacy of gemcitabine in pancreatic cancer by inducing endosomal escape. Cancer Letters 507: 97-111
Faisal M, Kim JH, Yoo KH, Roh EJ, Hong SS, Lee SH. (2021.01.14) Development and therapeutic potential of NUAKs inhibitors. Journal of Medicinal Chemistry. 64(1): 2-25
Chung DY, Song KM, Choi MJ, Limanjaya A, Ghatak K, Ock J, Yin GN, Hong CH, Hong SS, Suh JK, Ryu JK. (2021.01) Neutralizing antibody to proNGF rescues erectile function by regulating the expression of neurotrophic and angiogenic factors in a mouse model of cavernous nerve injury. Andrology. 9(1): 329-341
Song KM, Kim WJ, Choi MJ, Kwon KD, Limanjaya A, Ghatak K, Ock J, Yin GN, Sato Y, Hong SS, Ryu JK, Suh JK (2021.01.13) Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice. Scientific Reports. 11(1):1114
Yin GN, Ock J, Limanjaya A, Minh NN, Hong SS, Yang T, Longo FM, Ryu JK, Suh JK. (2021.1.1) Oral administration of the p75 neurotrophin receptor modulator, LM11A-31, improves erectile function in a mouse model of cavernous nerve injury. Journal of Sexual Medicine. 18(1): 17-28
2020
Yoon YC, Fang Z, Lee JE, Park JH, Ryu JK, Jung KH, Hong SS* (2020.11.01) Selonsertib inhibits liver fibrosis via downregulation of ASK1/ MAPK pathway of hepatic stellate cells. Biomolecules & Therapeutics. 28(6): 527-536
Jung SH, Lee W, Park SH, Lee KY, Choi YJ, Choi S, Kang D, Kim S, Chang TS, Hong SS, Lee BH (2020.10) Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: implications for hepatotoxicity. Redox Biology. 37:101751
Fang Z, Jung KH, Lee JE, Cho J, Lim JH, Hong SS* (2020.11) MEK blockade overcomes the limited activity of palbociclib in head and neck cancer. Translational Oncology. 13(11)100833
Song KM, Kim WJ, Choi MJ, Limanjaya A, Ghatak K, Minh NN, Ock J, Yin GN, Hong SS, Suh JK, Ryu JK. (2020.09) Intracavernous delivery of dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse. Andrology 8(5): 1387-1397
Jung KH, Son MK, Yan HH, Fang Z, Kim J, Kim SJ, Park JH, Lee JE, Yoon YC, Seo MS, Han BS, Ko S, Suh YJ, Lim JH, Lee DH, Teo Z, Wee JWK, Tan NS, Hong SS* (2020.08.07) ANGPTL4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a. EMBO Molecular Medicine. 12(8) e11222
Kim J, Jung KH, Choi JG, Oh MS, Hong SS* (2020.07) Artemisiae Iwayomogii herba inhibits growth, motility, and the PI3K/AKT/mTOR signaling pathway in hepatocellular carcinoma cells. Planta Medica 86(10): 717-727
Yoon YC, Fang Z, Lee JE, Park JH, Ryu JK, Jung KH, Hong SS* (2020.05.26) Selonsertib inhibits liver fibrosis via downregulation of ASK1/ MAPK pathway of hepatic stellate cells Biomolecules & Therapeutics. doi: 10.4062/biomolther.2020.016
Kim OH, Lee JH, Mah SM, Park SY, Hong S, Hong SS* (2020.03.19) HS-146, a novel phosphoinositide 3 kinase α inhibitor,induces the apoptosis and inhibits the metastatic ability of human breast cancer cells. International Journal of Oncology 56:1509-152
Kim J, Jung KH, Yoo J, Park JH, Yan HH, Fang Z, Lim JH, Kwon SR, Kim MK, Park HJ, Hong SS* (2020.03.01) PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis. Biomolecules & Therapeutics. 28(2): 172-183
2019
Kim J, Jung KH, Ryu HW, Kim DY, Oh SR, Hong SS* (2019.11.07) Apoptotic Effects of Xanthium strumarium via PI3K/AKT/mTOR Pathway in Hepatocellular Carcinoma Evidence-Based Complementary and Alternatative Medicine 2019:2176701
Anh NH, Long NP1, Kim SJ, Min JE, Yoon SJ, Kim HM, Yang E, Hwang ES, Park JH, Hong SS, Kwon SW (2019.09.21) Steroidomics for the prevention, assessment, and management of cancers: A systematic review and functional analysis. Metabolites 9, 1999
Yoon SJ, Long NP, Jung KH, Kim HM, Hong YJ, Fang Z, Kim SJ, Kim TJ, Anh NH, Hong SS, Kwon SW. (2019.09.06) Systemic and Local Metabolic Alterations in Sleep-Deprivation-Induced Stress: A Multiplatform Mass-Spectrometry-Based Lipidomics and Metabolomics Approach. J Proteome Res. 3295-3304
Kang YP, Yoon JH Long, NP, Koo GB, Noh HJ, Oh SJ, Lee SB, Kim HM, Hong JY, Lee WJ, Lee SJ , Hong SS, Kwon SW, Kim YS (2019.03.21) Spheroid-induced epithelial-mesenchymal transition provokes global alterations of breast cancer lipidome: A multi-layered omics analysis. Frontiers in Oncology 9: 145
Park JH, Jung KH, Kim SJ, Yoon YC, Yan HH, Fang Z, Lee JE, Lim JH, Mah S, Hong S, Kim YS, Hong SS* (2019.03.01) HS-173 as a novel inducer of RIP3-dependent necroptosis in lung cancer. Cancer Letters 444: 94-104
Lee SJ, Wang H, Ahn SH, Son MK, Hyun GH, Yoon SJ, Lee J, Park JH, Lim J, Hong SS*, Kwon SW (2019.02.11) Metabolomics approach based on multivariate techniques for blood transfusion reactions. Scientific Reports. 9:1740 (co-correspondent)
Long NP, Jung KH, Anh NH, Yan HH, Nghi TD, Park S, Yoon SJ, Min JE, Kim HM, Lim JH, Kim JM, Lim J, Lee S, Hong SS*, Kwon SW (2019.01.29) An integrative data mining and omics-based translational model for the identification and validation of oncogenic biomarkers of pancreatic cancer. (co-correspondent) Cancers 11(2): 155
Koo GB, Hong SS, Kwon SW, Kim YS (2019.01) A formulated red ginseng extract inhibits autophagic flux and sensitizes to doxorubicin-induced cell death. Journal of Ginseng Research 43:86-94
2018
Lee JH, El-Damasy AK, Seo SH, Gadhe CG, Pae AN, Jeong N, Hong SS*, Keum G (2018.11.15) Novel 5,6-disubstituted pyrrolo[2,3-d]pyrimidine derivatives as broad spectrum antiproliferative agents: Synthesis, cell based assays, kinase profile and molecular docking study. Bioorganic & Medicinal Chemistry 26(21): 5596-5611(co-correspondent)
Hong S, Fang Z, Jung HY, Yoon JH, Hong SS*, Maeng HJ. (2018.10.11) Synthesis of gemcitabine-threonine amide prodrug effective on pancreatic cancer cells with improved pharmacokinetic properties. Molecules 23(10):2608 (co-correspondent)
Long NP, Yoon SJ, Anh NH, Nghi TD, Lim DK, Hong YJ, Hong SS, Kwon SW (2018.08.10) A systematic review on metabolomics-based diagnostic biomarker discovery and validation in pancreatic cancer. Metabolomics.14:109
Jung KH, Rumman M, Yan H, Cheon MJ, Choi JG, Jin X, Park S, Oh MS, Hong SS* (2018.07.04) An ethyl acetate fraction of Artemisia capillaris (ACE-63) induced apoptosis and anti-angiogenesis via Inhibition of PI3K/AKT signaling in HCC. Phytotherapy Research 32(10):2034-2046
Kang YW, Lee JE, Jung KH, Son MK, Shin SM, Kim SJ, Fang Z, Yan HH, Park JH, Han B, Cheon MJ, Woo MG, Lim JH, Kim YS, Hong SS* (2018.09.11) KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer. Cancer Letters 438: 174-186
Park HH, Park SY, Mah S, Park JH, Hong SS*, Hong S, and Kim YS (2018.09.20) HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Experimental & Molecular Medicine. 50:125(co-correspondent)
Tran MH, Seo E, Min S, Nguyen QAT, Choi J, Lee UJ, Hong SS, Kang H, Mansukhani A, Jou I, Lee SY (2018.05.30) NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase α and its implication in breast cancer cell proliferation. Journal of Cellular and Molecular Medicine. 47(5):1751-1768
Fang Z, Han B, Jung KH, Lee JH, El-Damasy AK, Gadhe CG, Kim SJ, Yan HH, Park JH, Lee JE, Kang YW, Pae AN, Keum G, Hong SS* (2018.07) A novel tropomyosin-related kinase A inhibitor, KK5101 to treat pancreatic cancer. Cancer Letters 426:25-36
Fang J, Jung KH, Yan HH, Kim SJ, Rumman M, Park JH, Han B, Lee JE, Kang YW, Lim JH, Hong SS* (2018.06.28) Melatonin synergizes with sorafenib to suppress pancreatic cancer via melatonin receptor and PDGFR-β/STAT3 pathway. Cellular Physiology and Biochemistry 47:1751-1768
Choi SR, Hong SS, Kim J, Lee KY (2018.06) Neutrophil elastase in cervical fluid in women with short cervical length. Taiwanese Journal of Obstetrics & Gynecology 57(3): 407-410
Kim JY, Jung KH, Yan HH, Cheon MJ, Kang S, Jin X, Park S, Oh MS, Hong SS* (2018.05.08) Artemisia Capillaris leaves inhibit cell proliferation and induce apoptosis in hepatocellular carcinoma (2018.04) BMC Complementary and Alternative Medicine. 18:147
Yan H, Jung KH, Kim J, Rumman M, Oh MS, Hong SS* (2018.02) Artemisia capillaris extract AC68 induces apoptosis of hepatocellular carcinoma by blocking the PI3K/AKT pathway. Biomedicine & Pharmacotherapy 98:134-141
2017
Park JH, Jung KH, Kim SJ, Fang Z, Yan HH, Son MK, Kim JY, Kang Y, Lee JE, Han B, Lim JH , Hong SS* (2017.12) Radiosensitization of the PI3K Inhibitor HS-173 through reduction of DNA damage repair in pancreatic cancer. Oncotarget 8(68):112893-112906
Long NP, Jung KH,Yoon SJ, Anh NH, Nghi TD, Kang YP, Yan HH, Min JE, Hong SS*, Kwon SW (2017.11) Systematic assessment of cervical cancer initiation and progression uncovers genetic panels for deep learning-based early diagnosis and proposes novel diagnostic and prognostic biomarkers. Oncotarget 8(65): 109436-109456 (co-correspondent)
Mah S, Park JH, Jung HY, Ahn K, Choi S, Tae HS, Jung KH, Rho JK, Lee JC, Hong SS*, Hong S (2017.11.22) Identification of 4-phenoxyquinoline based inhibitors for L1196M mutant of ALK through structure-based design. Journal of Medicinal Chemistry 60(20):9205-9221 (co-correspondent)
Kim SJ, Jung KH, Son MK, Park JH, Yan HH, Fang Z, Kang YW, Han B, Lim JH, Hong SS* (2017.07) Tumor vessel normalization by the PI3K inhibitor HS-173 enhances drug delivery. Cancer Letters. 403:339-353
Jung KH, Choi IK, Lee HS, Yan HH, Son MK, Ahn HM, Hong J, Yun CO, Hong SS* (2017.06.28) Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine against pancreatic cancer. Cancer Letters. 396:155-166
Kim YJ, Jung K, Baek DS, Hong SS, Kim YS (2017.05.04) Co-targeting of EGF receptor and neuropilin-1 overcomes cetuximab resistance in pancreatic ductal adenocarcinoma with integrin β1-driven Src-Akt bypass signaling. Oncogene. 36(18):2543-2552
Choi MJ, Zheng HM, Park HD, Jeong HK, Hong SS, Kim JM, Lee DH (2017.05) Prokinetic effects of LD02GIFRO on functional gastrointestinal disorder in rats. Experimental and Therapeutic Medicine. 13: 2043-2049
2016
Oh ET, Kim JW, Kim JM, Kim SJ, Lee JS, Hong SS, Goodwin J, Ruthenborg RJ, Jung M, Lee HJ, Lee CH, Park ES, Kim C, Park HJ (2016. 12. 14) NQO1 stabilizes HIF-1α by inhibiting proteasome-mediated degradation. Nature Communications. 7:13593
Shin Y, Lim SM, Yan HH, Jung S, Fang Z, Jung KH, Hong SS*, Hong S (2016.11.10) Optimization and biological evaluation of aminopyrimidine-based IκB kinase β inhibitors with potent anti-inflammatory effects. European Journal of Medicinal Chemistry. 123: 544-556 (co-correspondent)
Rumman M, Jung KH, Fang Z, Yan HH, Son MK, Kim SJ, Kim JY, Park JH, Lim JH, Hong S, Hong SS* (2016.11.22) HS-173, a novel PI3K inhibitor suppresses EMT and metastasis in pancreatic cancer. Oncotarget. 7(47): 78029-78047
Kim E, Kim JM, Choi SJ, Park IS, Han JY, Chu YC, Choi ES, Na K, Hong SS (2016.09.13) The effect of neutral-surface iron oxide nanoparticles on cellular uptake and signaling pathways. International Journal of Nanomedicine. 11:4595-4607
Oh ET, Kim CW, Kim SJ, Lee JS, Hong SS*, Park HJ (2016.06.06) Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia. Scientific Reports. 6:27382 (co-correspondent)
Kwon MH, Park SH, Song KM, Ghatak K, Limanjaya A, Ryu DS, Ock J, Hong SS, Ryu JK, Suh JK. (2016.04.24) Penile erection induces angiogenic, survival, and antifibrotic signals: molecular events associated with penile erection induced by cavernous nerve stimulation in mice. International Journal of Urology 23(7): 614-622
Ahn J, Son MK, Jung KH, Kim K, Kim GJ, Lee SH, Hong SS*, Park SG (2016. 02) Aminoacyl-tRNA synthetase interacting multi-functional protein 1 attenuates liver fibrosis by inhibiting TGFβ signaling. International Journal of Oncology. 48(2):747-755 (co-correspondent)
Zheng HM, Choi MJ, Kim JM, Cha KH, Lee KW, Park YH, Hong SS, Lee DH. (2016.01) Centella asiatica leaf extract protects against indomethacin-induced gastric mucosal injury in rats. Journal of Medicinal Food. 19(1):38-46
2015
Jin SE, Jin HE, Hong SS* (2015.10) Targeting L-type amino acid transporter 1 for anticancer therapy: clinical impact from diagnostics to therapeutics. Expert Opinion on Therapeutic Targets. 19(10):1319-1337
Kim EC, Kim SH, Piao SJ, Kim TJ, Bae K, Kim HS, Hong SS, Lee BI, Nam M (2015.07) Antiangiogenic activity of acer tegmentosum maxim water extract in vitro and in vivo. Journal of Korean Medical Science 30(7):979-987
Lee JH, Park CH, Chun KH, Hong SS* (2015.07) Effects of adipose-derived stem cell-conditioned medium on the proliferation and migration of B16 melanoma cells. Oncology Letters 10:730-736
Hong SS, Choi JH, Lee SY, Kim J, Gajulapati K, Goo JI, Singh S, Park YH, Park KY, Lee JY, Lee K, Kim YK, Im SH, Ahn SH, Rose-John S, Heo TH, Choi Y, (2015.07) A novel small molecule inhibitor targeting the IL-6 receptor beta subunit, gp130. Journal of Immunology 195(1): 237-245
Koo GB, Morgan M, Lee DG, Kim WJ, Koo JS, Kim SI, Kim SJ, Son MK, Hong SS, Levy JM, Pollyea D, Jordan C, Yan P, Frankhouser D, Nicolet D, Maharry K, Marcucci G, Choi KS, Cho H, Thorburn A, Yoon JH, Kim YS (2015.06) Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics Cell Research 25(6):707-725
Fang Z, Jung KH, Yan HH, Kim SJ, Son MK, Rumman M, Lee H, Kim KW, Yoo HD, Hong SS* (2015.05.11) CD-200 induces apoptosis and inhibits Bcr-Abl signaling in imatinib-resistant chronic myeloid leukemia with T315I mutation. International Journal of Oncology. 47: 253-261
Jung KH, Yi T, Son MK, Song SU, Hong SS* (2015.05) Therapeutic effect of human clonal bone marrow-derived mesenchymal stem cells in severe acute pancreatitis. Archives of Pharmacal Research. 38(5): 742-751
Kim SJ, Jung KH, Yan HH, Son MK, Fang Z, Ryu YL, Lee H, Lim JH, Suh JK, Kim J, Lee S, Hong S, Hong SS* (2015.01.30) HS-543 induces apoptosis of Imatinib-resistant chronic myelogenous leukemia with T315I mutation. Oncotarget. 6(3):1507-1518
2014
Jang WJ, Park B, Jeong GS, Hong SS, Jeong CH (2014.12) SB365, Pulsatilla saponin D, suppresses the growth of gefitinib-resistant NSCLC cells with Met amplification. Oncology Reports. 32(6):2612-2618
Lee JH, Jung KH, Lee H, Son MK, Yun SM, Ahn SH, Lee KR, Lee S, Kim D, Hong S, Hong SS* (2014.10.30) HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy. Oncotarget. 5(20):10180-10197
Pack EC, Kim CH, Lee SH, Lim CH, Sung DG, Kim MH, Park KH, Hong SS, Lim KM, Choi DW, Kim SW (2014.10.24) Effects of environmental temperature change on mercury absorption in aquatic organisms with respect to climate warming. Journal of Toxicology and Environmental Health, Part A. 77:1477-1490
Yan HH, Jung KH, Son MK, Fang Z, Kim SJ, Ryu YL, Kim J, Kim MH, Hong SS* (2014.10.15) Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer. Oncotarget. 5(19):9150-9168
Ryu YL, Jung KH, Son MK, Yan HH, Kim SJ, Shin S, Hong S, Hong SS* (2014.10.10) Anticancer activity of HS-527, a novel inhibitor targeting PI3-kinase in human pancreatic cancer cells. Cancer Letters. 353(1):68-77
Jahrn A, Song CK, Balakrishnan P, Hong SS, Lee JH, Chung SJ, Kim DD (2014.08) AAPE proliposomes for topical atopic dermatitis treatment. Journal of Microencapsulation. 31(8):768-773
Lee S, Lee H, Kim JH, Lee S, Kim SJ, Hong SS*, Hong S (2014.07.16) Development and biological evaluation of potent and selective c-KITD816V inhibitors. Journal of Medicinal Chemistry. 57(15):6428-6443 (co-correspondent)
Kim DG, Jung KH, Lee DG, Yun JH, Choi KS, Kwon SW, Shen HM, Morgan MJ, Hong SS*, Kim YS (2014.06.30) 20(S)-ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin. Oncotarget. 5(12):4438-4451 (co-correspondent)
Jung KH, Yan HH, Fang Z, Son MK, Lee H, Hong S, Hong SS* (2014.07) HS-104, a PI3K inhibitor, enhances anticancer efficacy of gemcitabine in pancreatic cancer. International Journal of Oncology. 45(1):311-321
Yun SM, Jung KH, Kim SJ, Fang ZH, Son MK, Yan HH, Lee H, Kim JH, Shin S, Hong S, Hong SS* (2014.06.28) HS-438, a new inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia. Cancer Letters. 348:50-60
Jin SE, Jin HE, Hong SS* (2014.01) Targeted delivery system of nano-biomaterials in anti-cancer therapy: from cells to clinics. BioMed Research International 2014:814208
2013
Son MK, Ryu YL, Jung KH, Lee HS, Lee H, Yan HH, Park HJ, Ryu JK, Suh JK, Hong S, Hong SS* (2013.12.11) HS-173, a novel PI3K inhibitor, attenuates the activation of hepatic stellate cells in liver fibrosis. Scientific Reports. 3:3470
Jia S, Li J, Park SR, Ryu Y, Park IH, Park JH, Hong SS, Kwon SW, Lee J (2013.12) Combined application of dispersive liquid–liquid microextraction based on the solidification of floating organic droplets and charged aerosol detection for the simple and sensitive quantification of macrolide antibiotics in human urine. Journal of Pharmaceutical and Biomedical Analysis. 86:204-213
Hong SW, Jung KH, Lee HS, Son MK, Yan HH, Kang NS, Lee J, Hong SS* (2013.09) SB365, Pulsatilla saponin D targets c-Met and exerts antiangiogenic and anti-tumor activities. Carcinogenesis. 34(9):2156-2169
Seo JH, Jung KH, Son MK, Yan HH, Ryu YL, Kim J, Lee JK, Hong S, Hong SS* (2013.09) Anti-cancer effect of HS-345, a new tropomyosin-related kinase A inhibitor, on human pancreatic cancer. Cancer Letters. 338:271-281
Son MK, Jung KH, Lee HS, Lee H, Kim SJ, Yan HH, Ryu YL, Hong SS* (2013.08) SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells Oncology Reports. 30: 801-808
Lee YS, Lee DG, Lee JY, Kim TR, Hong SS, Kwon SW, Kim YS (2013.08) A formulated red ginseng extract upregulates CHOP and increases TRAIL-mediated cytotoxicity in human hepatocellular carcinoma cells. International Journal of Oncology. 43(2) 591-599
Lee H, Kim SJ, Jung KH, Son MK, Yan HH, Hong S, Hong SS* (2013.08) A novel imidazopyridine PI3K inhibitor with anticancer activity in non-small cell lung cancer cells. Oncology Reports. 30:863-869
Yun SM, Lee JH, Jung KH, Lee H, Lee S, Hong S, and Hong SS* (2013.07) Induction of apoptosis and suppression of angiogenesis of hepatocellular carcinoma by HS-159, a novel phosphatidylinositol 3-kinase inhibitor. International Journal of Oncology. 43(1):201-209
Hong S, Kim J, Yun SM, Lee H, Park Y, Hong SS*, Hong S (2013.05) Discovery of new benzothiazole-based inhibitors of breakpoint cluster region-Abelson kinase including the T315I mutant. Journal of Medicinal Chemistry. 56(9):3531-3545 (co-correspondent)
Jung KH, Ryu YL, Lee HS, Lee H, Son MK, Yan HH, Hong SW, Ryu JK, Hong S, Suh JK, Hong SS* (2013.06) A novel PI3K inhibitor alleviates fibrotic responses in fibroblasts derived from Peyronie’s Plaques. International Journal of Oncology. 42(6):2001-2008
Hong SW, Jung KH, Park BH, Zheng HM, Lee HS, Choi MJ, Yun JI, Kang NS, Lee J, Hong SS* (2013.05.10) KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer. Cancer Letters. 332(1):74-82
Park BH, Jung KH, Yun SM, Hong SW, Ryu JW, Jung H, Ha JD, Lee J, Hong SS* (2013.05.01) KRC-327, a selective novel inhibitor of c-Met receptor tyrosine kinase with anticancer activity. Cancer Letters. 331(2):158-166
Yun SM, Jung KH, Lee H, Son MK, Seo JH, Yan HH, Park BH, Hong S, Hong SS* (2013.05.01) Synergistic anticancer activity of HS-173, a novel PI3K inhibitor in combination with Sorafenib against pancreatic cancer cells. Cancer Letters. 331(2):250-261
Lee JY, Jung KH, Morgan M, Kang YR, Lee HS, Koo GB, Hong SS, Kwon SW, Kim YS (2013.05) Sensitization of TRAIL-induced cell death by 20S-Ginsenoside Rg3 via CHOP-mediated DR5 up-regulation in human hepatocellular carcinoma cells. Molecular Cancer Therapeutics. 12(3):274-285
Lee JH, Lee H, Yun SM, Jung KH, Jeong Y, Yan HH, Hong S, Hong SS* (2013.02) IPD-196, a novel phosphatidylinositol 3-kinase inhibitor with potent anticancer activity against hepatocellular carcinoma. Cancer Letters. 329(1):99-108
Lee GY, Jung KH, Lee H, Son MK, Seo JH, Hong SW, Jeong Y, Hong S, Hong SS* (2013.02) A novel imidazopyridine derivative, HS-106, induces apoptosis of breast cancer cells and represses angiogenesis by targeting the PI3K/mTOR pathway. Cancer Letters. 329(1):59-67
Ju HK, Chung HW, Lee HS, Lim J, Park JH, Lim SC, Kim JM, Hong SS*, Kwon SW (2013.1.1) Investigation of metabolite alteration in dimethylnitrosamine-induced liver fibrosis by GC-MS. Bioanalysis. (co-correspondent) 5(1):41-51
Lee HS, Jung KH, Jeong Y, Hong S, Hong SS* (2013.01) HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis. Cancer Letters. 328:152-159
Jung KH, Zheng HM, Jeong Y, Choi MJ, Lee H, Hong SW, Lee HS, Son MK, Lee S, Hong S, Hong SS* (2013.01) Suppression of tumor proliferation and angiogenesis of hepatocellular carcinoma by HS-104, a novel phosphoinositide 3-kinase inhibitor. Cancer Letters. 328:176-187
Son MK, Jung KH, Hong SW, Lee HS, Zheng HM, Choi MJ, Seo JH, Suh JK, Hong SS* (2013.01) SB365, Pulsatilla saponin D suppresses the proliferation of human colon cancer cells and induces apoptosis by modulating the AKT/mTOR signalling pathway. Food Chemistry. 136:26-33
Park BH, Jung KH, Son MK, Seo JH, Lee HS, Lee JH, Hong SS* (2013.01) Antitumor activity of Pulsatilla Koreana extract (PKE) in anaplastic thyroid cancer via apoptosis and antiangiogenesis. Molecular Medicine Reports. 7:26-30
2012
Hong SW, Jung KH, Lee HS, Lee HS, Choi MJ, Son MK, Zheng HM, Hong SS* (2012.11) SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway. Cancer Science. 103(11):1929-1937
Hong SW, Jung KH, Choi MJ, Kim DY, Lee HS, Zheng HM, Li GY, El-Deeb IM, Park BS, Lee SH, Hong SS* (2012.11) Anti-cancer effects of KI-10F: a novel compound affecting apoptosis, angiogenesis and cell growth in colon cancer. International Journal of Oncology. 41(5):1715-1722
Lee C, Hong C, Lee J, Son M, Hong SS (2012.09) Comparison of oxidized porous silicon with bare porous silicon as a photothermal agent for cancer cell destruction based on in vitro cell test results. Lasers in Medical Science. 27:1001-1008
Song CK, Lee JH, Jahn A, Choi MJ, Namgoong SK, Hong SS, Chong S, Shim CK, Chung SJ, Kim DD (2012.09) In vitro and in vivo evaluation of N,N,N-trimethylphytosphingosine-1 iodide (TMP) in liposomes for the treatment of angiogenesis and metastasis. International Journal of Pharmaceutics. 434:191-198
Hong SW, Lee HS, Jung KH, Lee HS, Hong SS* (2012.06.30) Protective effect of fucoidan against acetaminophen-induced liver injury. Archives of Pharmacal Research. 35(6):1099-1105
Hong S, Seo JH, Kim J, Jung KH, Hong SS*, Hong S (2012.06.14) Design, synthesis and evaluation of 3,5-disubstituted 7-azaindoles as Trk inhibitors with anticancer and antiangiogenic activities. Journal of Medicinal Chemistry. 55(11):5337-5349 (co-correspondent)
Hong C, An S, Son M, Hong SS, Lee DH, Lee C (2012.06) In vitro cell tests using doxorubicin-loaded polymeric TiO2 nanotubes used for cancer photothermotherapy. Anti-Cancer Drugs. 23(5):553-560
Lee H, Lee GY, Jung Y, Jung KH, Lee JH, Ham K, Hong S, Hong SS* (2012.5.01) A novel imidazopyridine analogue as a phosphatidylinositol 3-kinase inhibitor against human breast cancer. Cancer Letters 318(1):68-75
Choi MJ, Lee H, Lee JH, Jung KH, Kim D, Hong S, Hong SS* (2012.04.30) The effect of HS-111, a novel thiazolamine derivative, on apoptosis and angiogenesis of hepatocellular carcinoma cells. Archives of Pharmacal Research. 35(4):747-754.
Jung KH, Park BH, Hong SS* (2012.03) Progress in cancer therapy targeting c-Met signaling pathway. Archives of Pharmacal Research. 35(4):595-604
Jung KH, Choi MJ, Hong S, Lee H, Hong SW, Zheng HM, Lee HS, Hong S, Hong SS* (2012.3.28) HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K/AKT/mTOR pathway. Cancer Letters 316(2):187-195
Hong SW, Jung KH, Lee HS, Choi MJ, Zheng HM, Son MK, Hong SS* (2012.02) Apoptotic and antiangiogenic effects of Pulsatilla koreana extract (PKE) on hepatocellular carcinoma International Journal of Oncology 40(2):452-460
2011
Hong C, Lee J, Son M, Hong SS, Lee C (2011.11) In vivo cancer cell destruction using porous silicon nanoparticle. Anti-Cancer Drugs 22(10):971-977
Choi MJ, Jung KH, Kim D, Lee H, Zheng HM, Park BH, Hong SW, Kim MH, Hong S, Hong SS* (2011.7.28) Anti-cancer effects of a novel compound HS-113 on cell growth, apoptosis, and angiogenesis in human hepatocellular carcinoma cells. Cancer Letters 306(2):190-196
Hong SW, Jung KH, Lee HS, Zheng HM, Choi MJ, Lee C, Hong SS* (2011.5.30) Suppression by fucoidan of liver fibrogenesis via TGF-β/Smad pathway in protecting against oxidative stress. Bioscience Biotechnology and Biochemistry 75(5):833-840
Hong C, Lee J, Zheng H, Hong SS, Lee C (2011.04) Porous Silicon Nanoparticles for Cancer Photothermotherapy. Nanoscale Research Letters. 6(1):321
Kim D, Jun H, Lee H, Hong SS*, Hong S (2011.04.15) Fluorescent phosphoinositide 3-kinase inhibitors suitable for monitoring of intracellular distribution. Bioorganic & Medicinal Chemistry 19(8):2508-2516
Kim O, Jeong Y, Lee H, Hong SS*, Hong S (2011.04) Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis. Journal of Medicinal Chemistry. 54:2455-2466
Jung KH, Song SU, Yi TG, Jeon MS, Hong SW, Zheng HM, Lee HS, Choi MJ, Lee DH, Hong SS* (2011.03.01) Human bone marrow-derived clonal mesenchymal stem cells alleviate acute pancreatitis by inhibiting inflammatory response. Gastroenterology. 140:998-1008
Kwon HN, Kim MA, Wen H, Kang S, Yang HJ, Choi MJ, Lee HS, Park IS, Suh YJ, Hong SS*, Park S (2011.03) Predicting idiopathic toxicity of the anticancer agent cisplatin with a pharmacometabonomic approach. Kidney International. 79(5):529-537
Yang HJ, Choi MJ, Wen H, Kwon HN, Jung KH, Hong SW, Kim JM, Hong SS*, Park S (2011.02) An effective assessment of simvastatin-induced toxicity with NMR-based metabonomics approach. PLoS ONE 6(2):e16641
Cho HJ, Balakrishnan P, Park EK, Song KW, Hong SS, Jang TY, Kim KS, Chung SJ, Shim CK, Kim DD (2011.02) Poloxamer/cyclodextrin/chitosan-based thermoreversible gel for intranasal delivery of fexofenadine hydrochloride. Journal of Pharmaceutical Sciences. 100(2):681-691
Lee JH, Lee H, Joung YK, Jung KH, Choi JH, Lee DH, Park KD, Hong SS* (2011.2) The use of low molecular weight heparin-pluronic nanogels impedes liver fibrosis by inhibiting the TGF-β/Smad signaling pathway. Biomaterials. 32(5):1438-1445
Wen H, Yang HJ, Choi MJ, Kwon HN, Kim MA, Hong SS, Park S (2011.01) Identification of urinary biomarkers related to cisplatin-induced acute renal toxicity using NMR-based metabonomics. Biomolecules & Therapeutics. 19(1):38-44
2010
Hong S, Lee S, Kim B, Lee H, Hong SS*, Hong S (2010.12) Discovery of new azaindole-based PI3Ka inhibitors: apoptotic and antiangiogenic effect on cancer cells. Bioorganic & Medicinal Chemistry Letters. 20(24):7212-7215
Lee HS, Lee JH, Jung KH, and Hong SS* (2010.10) Deguelin promotes apoptosis and inhibits proliferation of gastric cancer. Oncology Reports. 24(4):957-963
Hong C, Kang J, Lee J, Zheng HM, Hong SS, Lee DH, Lee C (2010.06.30) Photothermal therapy using TiO2 nanotubes in combination with near-infrared laser. Journal of Cancer Therapy. 1:52-58
Maeng JH, Lee DH, Jung KH, Bae YH, Park IS, Jeong S, Jeon YS, Shim CK, Kim W, Kim JA, Lee J, Lee YM, Kim JH, Kim WH, Hong SS* (2010.06) Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer. Biomaterials. 31(18):4995-5006
Hong SW, Jung KH, Zheng HM, Lee HS, Suh JK, Park IS, Lee DH, and Hong SS* (2010.04) The protective effect of resveratrol on dimethylnitrosamine-induced liver fibrosis in rats. Archives of Pharmacal Research. 33(4):601-609
Jung KH, Hong SW, Zheng HM, Lee HS, Lee H, Lee DH, Lee SY, Hong SS* (2010.04.01) Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats. Journal of Pineal Research. 48(3):239-250
Kim D, Jun H, Lee H, Hong SS*, Hong S (2010.03.19) Development of new fluorescent xanthines as kinase inhibitors. Organic Letters. 12(6):1212-1215. (co-correspondent)
Ju HK, Chung HW, Hong SS, Park JH, Lee J, Kwon SW (2010.03.15) Effect of steam treatment on soluble phenolic content and antioxidant activity of the Chaga mushroom (Inonotus obliquus). Food Chemistry. 119(2):619-625
2009
Lee H, Ryu SH, Hong SS, Seo DD, Min HJ, You E, Chung YH, and Kim KW (2009.08) Overexpression of metastasis-associated protein 2 is associated with hepatocellular carcinoma size and differentiation. Journal of Gastroenterology and Hepatology. 24:1440-1455
Ryu JK, Piao S, Shin HY, Choi MJ, Zhang LW, Jin HR, Kim WJ, Han JY, Hong SS, Park SH, Lee SJ, Kim IH, Lee CR, Kim DK, Mamura M, Kim SJ, Suh JK. (2009.05.18) IN-1130, a novel transforming growth factor-beta type I receptor kinase (activin receptor-like kinase 5) inhibitor, promotes regression of fibrotic plaque and corrects penile curvature in a rat model of Peyronie's disease. Journal of Sexual Medicine. 6(5):1284-1296
Lee SY, Gim GT, Roh SH, Song JS, Kim HJ, Hong SS, Kwon SW, Park JH. (2009.04.23) Proteomic analysis of the anti-cancer effect of 20S-ginsenosides Rg(3) in human colon cancer cell lines. Bioscience Biotechnology and Biochemistry. 73(4):811-816
Lee SY, Gim GT, Roh SH, Song JS, Kim HJ, Hong SS, Kwon SW, Park JH. (2009.04) Proteome changes related to the anti-cancer activity of HT29 cells by the treatment of ginsenoside Rd. Pharmazie. 64(4):242-247
Ju HK, Cho EJ, Jang MH, Lee YY, Hong SS, Park JH, Kwon SW (2009.04.05) Characterization of increased phenolic compounds from fermented Bokbunja (Rubus coreanus Miq.) and related antioxidant activity. Journal of Pharmaceutical and Biomedical Analysis. 49 (3):820-827
Jin HE, Hong SS, Choi MK, Maeng HJ, Kim DD, Chung SJ, Shim CK (2009.03.01) Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestadiol-induced cholestasis. Pharmaceutical Research. 26:549-559
Pyo JS, Roh SH, Kim DK, Lee JG, Lee YY, Hong SS, Kwon SW, Park JH (2009.02) Anti-cancer effect of betulin on a human lung cancer cell line: a pharmacoproteomic approach using 2 D SDS PAGE coupled with nano-HPLC tandem mass spectrometry. Planta Medica. 75(2): 127-131
2008
Kwon YM, Lee SD, Kang HS, Cho MG, Hong SS, Park CK, Lee JX, Jeon BS, Ko SR, Shon HJ, Choi DW (2008.12) Rapid and simultaneous determination of ginsenosides Rb1, Rb2, Rc and Re in Korean red ginseng extract by HPLC using Mass/Mass spectrometry and UV detection. Journal of Ginseng Research. 32(4):390-396
Kim H, Lee JM, Lee DH, Hong SS (2008.11) Enhancement in photoluminescence of porous silicon deposited by sputtering an ultrathin silver film. Journal of the Korean Physical Society. 53(5):2562-2567
Park S, Kim H, Lee JM, Lee DH, Hong SS (2008.10) Synthesis of very straight bismuth oxide nanowires by using thermal evaporation of bismuth powders. Journal of the Korean Physical Society. 53:1965-1970
Lee JM, Kim H, Hong C, Kim MA, Hong SS, Lee DH, Lee WI (2008.09) Porous silicon as an agent for cancer thermotherapy based on near-infrared light irradiation. Journal of Materials Chemistry. 18:4790-4795
Malthankar-Phatak GH, Patel AB, Xia Y, Hong S, Chowdhury GM, Behar KL, Orina IA, Lai JC. (2008.09) Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons. Brain Research. 1229:147-154
2007
Choi MY, An YJ, Kim SH, Roh SH, Ju HK, Hong SS, Park JH, Cho KJ, Choi DW, Kwon SW (2007.12) Mass spectrometry based proteomic analysis of human stem cells: a brief review. Experimental and Molecular Medicine. 39:690-695
Jun HO, Kim Y, Kwon YW, Hong SS, Kim KW, Shin J, Kim TY (2007.10) Anti-angiogenic activity of Wondonin, a novel compound, inhibits hypoxia-induced angiogenesis through hypoxia inducible factor 1 alpha. FEBS Letters. 581(25):4977-4982
Oh SH, Woo JW, Yazici YD, Myers JN, Kim WY, Jin Q, Hong SS, Park HJ, Suh YG, Kim KW, Hong WK, Lee HY (2007.06.20) Structural basis for depletion of heat shock protein 90 client proteins by the natural antitumor agent deguelin. Journal of the National Cancer Institute. 99:949-961
Hong SS*, Park JH, Kwon SW (2007.01) Determination of proteins in infant milk formula by nano-high performance liquid chromatography-electrospray tandem mass spectrometry. Journal of Chromatography B. 845:69-73
2006
이전
Sung JH, Hong SS, Ahn SH, Li H, Seo SY, Park CH, Park BS, Chung SJ (2006.05) Mechanism for increased bioavailability of tacrine in fasted rats. Journal of Pharmacy & Pharmacology. 58:643-649
Zhang JH, Qian H, Zhao P, Hong SS, Xia Y (2006.04) Rapid hypoxia-preconditioning protects cortical neurons from glutamate toxicity through δ-opioid receptor. Stroke. 37:1094-1099
Choi MK, Song IS, Park SR, Hong SS, Kim DD, Chung SJ, Shim CK (2005.02) Mechanism of the stationary canalicular excretion of tributylmethyl ammonium in rats with a CCl4-induced acute hepatic injury. Journal of Pharmaceutical Sciences. 94(2):317-326